Emulate Liver-Chip R1: A Human-Relevant Model Of The Liver Sinusoid

Drug development is a complex, costly process, typically taking over a decade and requiring billions of dollars to bring a new drug to market. Traditional preclinical safety testing using in vitro models or animal studies often fails to accurately predict human responses, contributing to the high failure rate of clinical trials. To address this gap, Emulate developed the Chip-S1^® Stretchable Chip, which mimics human organ environments with high relevance by utilizing stretchable, biocompatible materials. However, a limitation of this model is its tendency to absorb certain drugs, potentially affecting predictions of drug behavior. To overcome this, Emulate introduced the Chip-R1 Rigid Chip, which minimizes drug absorption while preserving the essential 3D architecture. This new model enables the development of organ-chip systems for tissues that do not require stretch, such as the liver, kidney, brain, and lung. The Chip-R1 Liver model has shown promise in predicting drug hepatotoxicity, as demonstrated in an equivalency study. Explore the results from this study.