05.02.26 -- Drug Discovery Online Best Of April

Panel explored open source AI tools in drug discovery, from structure prediction to antibiotics, with leaders from Boltz, OpenFold, McMaster University, and Drug Discovery Online.

Chief Editor Louis Garguilo examines an outlandish but provocative question: would U.S. biotech survive without government funding, or does the industry depend on public support?

AI is naturally situated for NAMs, and its value will be maximized when it is deployed as part of a rigorously validated, evidence-based strategy.

Gain practical guidance for advancing bRo5 candidates through improved permeability and metabolic stability with insights on ECCS classes 3 and 4, optimized in vitro tools, and design principles.

See how PBPK models combined with custom and off-the-shelf in vitro tools and solubility enhancement expertise can reduce the need for drug product reformulation or repeated preclinical or clinical studies.

Gain insight into an automated high‑input workflow that streamlines long‑read whole‑genome library prep, supporting large DNA fragments while reducing reagent use.