Newsletter | December 23, 2025

12.23.25 -- 2025's Top 5 Drug Discovery Highlights And How To Stay Ahead In 2026

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The Non-Opioid Pain Therapeutics Summit provides a dedicated platform to harness the current momentum in the pain space. Attendees will be learning from companies with approvals such as Tonix and Vertex, exploring late-stage strategies from innovators like Latigo and Algiax, and uncovering discovery breakthroughs from Nocion and Axonis. Join discovery, preclinical, translational and clinical industry-based experts driving the future of non-opioid pain therapies.

FEATURED EDITORIAL

2025's Top 5 Drug Discovery Highlights And How To Stay Ahead In 2026

Drug Discovery Online's 2025 Top 5 most consequential shifts affecting this rapidly evolving field, including NAMs, AI, Individualized Therapies, Innovating China, and Early-stage Funding Volatility.

When One Gene Isn't Enough: The Case For Gene-Agnostic Vision Rescue

The genetic diversity of retinitis pigmentosa challenges the one-gene-one-therapy model and positions RP as a proving ground for gene-agnostic treatments designed to preserve or restore visual function across genotypes.

How Can We Develop New Treatments For Patients With Early Breast Cancer?

Intensity Therapeutics has developed a new approach to treating cancer — a therapy injected directly into tumors that kills cancer and stimulates a potent anticancer immune response.

INDUSTRY INSIGHTS

Early-Stage Drug Development: Trends That Shape Tomorrow's Therapies

From AI to adaptive trial designs, the industry is undergoing a transformation that is equal parts scientific breakthrough and strategic recalibration. Learn what innovations are poised to redefine pipelines.

Dissecting Cellular Composition Using Single-Cell Multiomics

Hear from Dr. Fabio Luciani, Professor and Senior Researcher in Systems Immunology at the School of Medical Sciences and the Kirby Institute at UNSW Sydney about his recent research.

Enabled Form Selection For Oral Drug Products

Review the role of solid form screening and PBPK modeling to enable accelerated timelines desirable in early-phase drug development. Explore formulation maps for ASDs and key criteria for salt screening.

Mammalian Display Method For Enhanced Affinity Biologics

Discover how mammalian display enhances T cell receptor-based cancer therapies. This method improves antigen affinity and reduces immunogenicity for more effective treatments.

How To Keep Your Degrader Pipeline Moving Forward

See a new biophysical method that simplifies PROTAC characterization, improves assay development, and delivers high-quality affinity data even for complex interactions.

Innovative Technology For Developing, Scaling Peptide-Based Therapeutics

Watch as experts walk through several technologies and case studies, focusing on liquid-phase peptide synthesis, crystallization, method development for impurity analysis, and more.

Implement Solvent Recycling To Reduce Waste And CO2 Emissions

Creating a greener manufacturing platform that accommodates solvent recovery and recycling requires careful consideration of your resources, procedures, and partnerships to achieve cost-effective goals.

Cell Line Development For Multi-Chain Biologics

Uncover the application of a platform in creating CHO cell lines for manufacturing multi-chain biologics, emphasizing the uniformity of the pools generated by this platform and the rapid selection of them.

SOLUTIONS

Award-Winning Preclinical Research Services

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