Altasciences Featured Articles
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Sinclair Nanopig™: Multi-Omics To Pharmacology And Toxicology
2/25/2025
Consider the potential of Sinclair Nanopig™ as a next-generation non-rodent model to enhance drug development, improve regulatory pharmacology, and reduce reliance on traditional non-rodent models.
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Procedure For Repeated Ultrasound Guided Liver Biopsies In NHPs
2/25/2025
Ultrasound-guided liver biopsies offer a safe, minimally invasive method for repeated tissue collection in non-human primates, ensuring reliable results with minimal animal stress and recovery time.
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The FDA Animal Rule And Standard For Exchange Of Nonclinical Data
2/25/2025
Support the development of standardized SEND guidelines for Animal Rule studies to ensure accurate and consistent regulatory submissions for acute radiation syndrome research.
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LC-MS/MS Assay For CTI-1601 In Monkey Tissues: Disposition, Processing
2/25/2025
A robust LC-MS/MS assay to quantify CTI-1601 in cynomolgus monkey tissues is essential for understanding its disposition and processing, supporting its potential as a protein replacement therapy.
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Translatability Of NHP Cytokine Data To In-Life Parameters In Toxicology Studies
2/25/2025
For accurate immunotoxicity assessment, cytokine data should be interpreted alongside clinical observations, body weight, and clinical pathology parameters.
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Detection Of Peripheral Blood Foxp3+ Regulatory T Cell Population
2/25/2025
Consider our robust and reproducible method for detecting Foxp3+ Tregs in cynomolgus monkeys, which enables a more effective evaluation of immunotherapies targeting Treg modulation.
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Effect Of Housing On Stress-Related Parameters In NHPs
2/25/2025
Explore how housing conditions impact stress levels in non-human primates and their relevance to toxicology studies, highlighting the potential benefits of gang housing.
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Development Of An IL-31-Induced Pruritus Model In Cynomolgus Monkeys
2/25/2025
Explore the potential of the cynomolgus monkey model with IL-31 pruritus to advance research and development of effective treatments for atopic dermatitis and other pruritic skin diseases.
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Use Of Thromboelastography (TEG) In Preclinical Studies
2/25/2025
Leverage TEG alongside conventional hematology to enhance the evaluation of coagulation disorders and provide more comprehensive insights into drug development and bleeding disorders.
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LC-MS/MS Determination Of Pirfenidone And Metabolites In Rat Plasma
2/25/2025
Explore the feasibility and efficiency of using a single assay coupled with LC-MS/MS for quantifying Pirfenidone and its metabolites in rat plasma, ensuring precision, accuracy, and separation.