Newsletter | October 7, 2025

10.07.25 -- Tyra Crystallizing The First Oral FGFR3 Therapy For Achondroplasia

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Join Drug Discovery Live on October 21 at 1pm ET for a virtual panel discussion on The NAMs Revolution: Smarter, Safer, More Ethical Drug Testing. Registration is free.

FEATURED EDITORIAL

Tyra Crystallizing The First Oral FGFR3 Therapy For Achondroplasia

Tyra Biosciences is using its SNÅP drug discovery platform to develop dabogratinib, the first oral FGFR3-selective therapy for achondroplasia, currently recruiting patients in Phase 2 trials.

INDUSTRY INSIGHTS

Optimized Expression Systems For Increased Productivity

Discover innovative strategies to boost CHO DG44 cell line productivity, as well as explore optimized expression systems that enhance yield, stability, and efficiency in protein development.

Advanced Analytical Tools To De-Risk Pharmaceutical Development

Consider using these three tools that facilitate a successful journey from candidate compound to clinical triumph: solid form screening, PBPK modeling, and AI-enabled route scouting.

Extractables And Leachables: Risk Management And Analytical Solutions

Partnering with a CDMO that offers comprehensive and robust E&L studies can help facilitate a smooth product launch by ensuring minimal impact from impurities, all while mitigating risks.

Budget For Drug Development Without Breaking The Bank Or Your Molecule

Early-stage biopharma teams face tough choices in injectable development. A strategic middle ground may be the smartest path to avoid the risk of under- and overspending.

PBPK Modeling: Mitigating Absorption Risks In Early Drug Development

Watch how PBPK models combined with in vitro tools and solubility enhancement expertise can be used to identify and mitigate absorption risks in early drug development.

An Alternative Genetic Engineering Tool In CHO Cells

See how transposon technology is being reimagined as a genetic engineering tool to create high-performing CHO cell lines for biotherapeutic production with enhanced metabolic and glycan profiles.

Optimized Urine Liquid Biopsy Workflow

Urine-derived cell-free DNA is revolutionizing liquid biopsy research to offer a non-invasive, accessible tool for early disease detection, monitoring, and comprehensive diagnostics across oncology.

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SOLUTIONS

Altasciences' Preclinical Services

On- And Off-Target Gene Editing Assessment Services

Flow Cytometry Sample Preparation System

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View the full agenda now for the 7th Inflammasome Therapeutics Summit (November | Boston, MA) - the leading event focused on inflammasome-targeted drug development. As clinical data begins to emerge from companies like NodThera, Ventus, and Ventyx, the field is approaching breakthrough moments. Join 70+ experts to explore the latest advances across neuroinflammation, metabolic, and autoimmune diseases, share insights, assess combination therapies, and shape the future of inflammasome-based clinical innovation.