Application Note

Technology Selection To Enhance Bioavailability

Source: Lonza Pharma & Biotech

By Dr. David K. Lyon, Ph.D., Senior Fellow, Research

Improved Bioavailability

Bioavailability challenges are among the toughest problems faced by today’s formulators. Most of the prospective drugs in pharmaceutical pipelines today have low solubility, which means the active therapeutic ingredients can’t be absorbed when patients take them orally. In many cases, this low bioavailability can mean promising medicines are abandoned because no technology can be identified that delivers the required therapeutic dose conveniently.

To solve this critical problem—which industry experts estimate affects as many as 7 in 10 of the compounds in pharmaceutical pipelines today—numerous approaches have been developed. These include the use of salts, cocrystals, amorphous solid dispersions, and nano- or microcrystals manufactured with a variety of technologies—spray drying, particle-size reduction, hot-melt extrusion (HME), cyclodextrin complexation, and lipid-based technologies. These approaches may enable development of low-solubility compounds, bringing new medicines to market or reformulating existing products to improve performance, extending the product lifecycle.

However, the wide array of these enabling technologies spawns another dilemma for formulators: how to choose the optimum technology from among this sea of choices. What factors need to be considered and how can the selection process be streamlined so the development of promising compounds is not delayed?

At Lonza, we’ve studied technology selection in depth and developed a science-based process to guide development of low-solubility compounds to improve bioavailability. Our approach recognizes several important facts.

VIEW THE APPLICATION NOTE!
Signing up provides unlimited access to:
Signing up provides unlimited access to:
  • Trend and Leadership Articles
  • Case Studies
  • Extensive Product Database
  • Premium Content
HELLO. PLEASE LOG IN. X

Not yet a member of Drug Discovery Online? Register today.

ACCOUNT SIGN UP X
Please fill in your account details
Login Information
I'm interested in newsletter subscriptions.
ACCOUNT SIGN UP

Subscriptions

Sign up for the newsletter that brings you the industry's latest news, technologies, trends and products.

You might also want to: