Selective Degradation Of Cancer Target WDR5 — Evaluation Of PROTACs Binary And Ternary Affinities With Spectral Shift

As the race to develop effective PROTACs intensifies, many companies are targeting notoriously undruggable cancer proteins—such as those involved in transcription regulation and signal transduction. These targets often present significant hurdles in biophysical characterization, particularly when it comes to understanding binary and ternary complex interactions. Without the right tools, these challenges can slow progress and compromise competitiveness. This webinar explores how Dianthus, a plate-based affinity screening platform powered by Spectral Shift technology, enables precise and efficient characterization of PROTAC interactions. Using five PROTACs targeting WDR5, a key cancer-related protein, the session demonstrates how Dianthus can streamline development and provide critical insights into degrader performance.

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