Application Note

Process Control And Performance Of The Allegro™ Connect Virus Filtration System

By Nigel Jackson

Allegro Connect Virus Filtration System

The Allegro™ Connect Virus Filtration System is a single-use automated filtration system designed to deliver robust process control and integrity assurance during this critical purification step.

This next generation compact system is designed to minimize risk through a fully automated process with recipe-controlled steps. These include pre-use manifold leak testing, pre-use and post-use filter integrity testing (utilizing an integrated Palltronic® Flowstar IV Integrity Test Instrument), system priming, product filtration and buffer chase, with all data stored in a batch reporting system. This system improves process control by significantly reducing non-conformities and manual labor.

New innovative design features allow manifold configurability to meet a variety of process needs, supporting a wide range of liquid filter capsules (prefilters and virus filters) while also accommodating filters from alternative manufacturers.

Explore the processing control of the Allegro™ Connect Virus Filtration System through the parameters of flow and pressure, critical to virus filtration performance, along with the rapid recovery (100%) of protein from material held up inside filter membrane and capsules during processing.

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