Performing Large Scale Targeted Peptide Quantification

There are many powerful workflows available for proteomics research on today’s mass spectrometry systems, depending on project goals. They cover a wide range that includes fully untargeted data dependent acquisition approaches for protein identification, comprehensive data independent acquisition strategies for large scale quantification, and also fully targeted quantitative assays for the highest specificity and sensitivity. This last class of assay has been typically performed on triple quadrupole or QTRAP systems because of their very high sensitivity and speed.

This study examines the ZenoTOF 7600 system, a QTOF system that can collect high-resolution, high mass accuracy, full-scan MS and MS/MS data. With Zeno trap technology, the system also demonstrates very high sensitivity MS/MS data.