Application Note

Optimizing Time And Cost Efficiency In Cell Line Development With StreamLink® CC 15

Source: Sartorius

By Hannes Korndörfer, Heiko Dinter, Magnus Warnke, Alexandra Stützer, James Edwards

GettyImages-1790780939-cell-culture-lab

Explore how the StreamLink® CC 15 system optimizes time and cost efficiency in cell line development (CLD) and automates downstream processes, including cell culture clarification and monoclonal antibody (mAb) purification. The increasing demand for mAbs necessitates faster, more cost-effective solutions in the biopharmaceutical industry. While the Ambr® 15 system has enhanced upstream CLD, the StreamLink® CC 15 addresses the bottleneck in downstream processing.

The StreamLink® CC 15 system processes up to 48 samples in one run, offering fully automated handling from clarification using Sartoclear® Disc filters to purification via Sartobind® Rapid A Nano membranes. Compared to conventional chromatography systems, StreamLink® CC 15 reduces purification time from 120 minutes to just 10 minutes per sample. Automation minimizes human error and provides reproducibility, while faster workflows eliminate the need for freezing samples, preserving product quality.

Cost analysis shows significant savings in full-time equivalent (FTE) labor, as StreamLink® CC 15 requires less hands-on time and fewer interventions. Processing 48 samples takes approximately 20 hours with StreamLink® CC 15, compared to 120 hours with traditional methods. Automated features allow for overnight, walk-away operation, further enhancing productivity.

The combination of speed, reduced labor, and consistent results makes the StreamLink® CC 15 an efficient solution for biopharmaceutical companies. It aligns with the industry's need to reduce time-to-market and operational costs, setting a new standard for downstream processing in CLD.

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