Newsletter | October 7, 2025

10.07.25 -- Novel Preclinical Models To Advance Oncology Therapeutics

Preclinical Technique To Assess Therapies For Primary, Metastatic NSCLC

Lung cancer remains a formidable challenge in healthcare as the leading cause of cancer-related fatalities. To enable comprehensive evaluation of therapies targeting both primary and metastatic tumors, we've developed dual-disease xenograft models using bioluminescence imaging (BLI).

 

BxPC-3: Evaluating Responses To Standard Therapeutic Agents

Pancreatic cancer has a projected incidence of 18.6 per 100,000 by 2050. Review multiple studies utilizing the BxPC-3 human pancreatic cancer model in subcutaneous (SC) NSG and NSG-dKO mouse models, evaluating a range of standard agents, vehicles, and delivery methods.

 

NIH:OVCAR-3 Human Ovarian Cancer Model

In an attempt to unravel the complexities of ovarian cancer, we've put together a study examining the NIH:OVCAR-3 model of the human gynecological malignancy in the subcutaneous setting in NSG mice with multiple standard agents and vehicles.

 

Advancing ADC Development: Overcoming Preclinical Challenges

Our scientific team provides the necessary support to accelerate the journey of promising ADC candidates from early discovery to clinical development, ultimately enhancing the success rate of translating preclinical discoveries into effective cancer treatments.

 

Overcoming Unique Challenges With A Strong Collaborative Partnership

Through close collaboration, proactive communication, and agile project management, see how our partnership was able to accelerate an oncology program and help overcome complex preclinical hurdles with efficiency and precision.

 

SOLUTIONS

Advancing Oncology Research With Discovery Services

Find discovery oncology solutions that consist of in vitro assessments, in vivo pharmacology services, in vivo imaging technologies, and focal radiation capabilities to support your oncology research programs.

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