Intensifying Chromatography With A Scalable Sartorius Rapid Cycling Platform Supporting High Productivity And Full Single-Use Application

By Luca Stähelin, Christian Köhler, and Mario Grünberg

Convective materials, such as membranes and monoliths, feature large pores that enable high flow rates, making them well-suited for Rapid Cycling Chromatography (RCC). This approach allows a single, compact membrane to process products across multiple cycles.

To maximize the benefits of membrane-based RCC, chromatography systems must meet specific criteria:

• High Flow Rates: Efficient fractionation requires short valve transition times and optimized flow paths.
• Fast Response Times: Quick transitions between purification stages are vital for seamless operation.

This poster highlights the capabilities of two new Sartorius chromatography systems, demonstrating their effectiveness for RCC and the potential of membrane-based ion exchange and affinity chromatography.