Newsletter | September 2, 2025

09.02.25 -- From Undruggable To Druggable: The Science Reshaping Small Molecule Discovery

FEATURED EDITORIAL

From Undruggable To Druggable: The Science Reshaping Small Molecule Discovery

For decades, most biologically validated disease-relevant protein targets have remained chemically inaccessible, thereby resisting conventional small molecule approaches. But now, a new wave of scientific innovation is paving a way forward.

INDUSTRY INSIGHTS

The Value Of Tailoring Transposons For Optimized Biotherapeutic Production

By leveraging transposase and transposon technologies that can achieve semi-targeted integration, researchers can generate transposon integration that primarily integrates a single copy at each site. 

How Do I Select The Right Species For My Toxicology Program?

Dive into the scientific rationale driving species selection for your nonclinical program, including how in vitro species comparison studies can help to determine the right species for your in vivo program.

The Power Of AI And Route Scouting To Navigate API Complexity

Using AI tools for retrosynthesis can help you investigate molecules interactively to build a complex API manufacturing process that maintains your timeline and saves you money.

Early Solid Form Screening To Guide Drug Development

Conducting solid form screening early can help your team select and isolate the ideal lead polymorph to ensure manufacturability and stability while avoiding costs and hiccups down the road.

Adapting To Change – API Custom Development And Manufacturing

A pharmaceutical company sought a development and manufacturing partner to assist with an in-licensed product originating from a pharma company, a molecule in clinical Phase II / III trials.

SOLUTIONS

CHO Cell Line Development Services For Therapeutic Protein Development