Case Study

Engineering Approaches To Respiratory Drug Delivery: Mannitol Case Study

Source: Lonza

By Cameron Kadleck, Respiratory Scientist, Product Development, Jimmy Beaty, Respiratory Scientist, Product Development, Matthew Ferguson, Ph.D., Senior Principal Investigator

Lonza 1

Spray drying and jet milling are commercially viable engineering processes for the development of respirable drug products. This article presents a case study that explores the material and performance properties of spray-dried and jet-milled mannitol for respiratory delivery of crystalline mannitol. The head-to-head comparison reveals opportunities and risks for designing a product based on each approach. It also explores the pros and cons of spray drying versus jet milling, describes how to use risk assessments to inform engineering technology selection, and illustrates how particle morphology affects aerodynamic performance.

access the Case Study!

Get unlimited access to:

Trend and Thought Leadership Articles
Case Studies & White Papers
Extensive Product Database
Members-Only Premium Content
Welcome Back! Please Log In to Continue. X

Enter your credentials below to log in. Not yet a member of Drug Discovery Online? Subscribe today.

Subscribe to Drug Discovery Online X

Please enter your email address and create a password to access the full content, Or log in to your account to continue.


Subscribe to Drug Discovery Online