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By Christina M. Celluzzi, Association for the Advancement of Blood & Biotherapies | New research concludes that potency cannot be decoupled from a product's mechanism of action because surrogate markers fail to capture functional relevance. | |
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| Proximity Inducers In Drug Discovery - A Perspective On Cooperativity | Case Study | An interview with Dr. Hans-Jörg Roth, former director of global discovery chemistry at Novartis, NanoTemper Technologies, Inc. | Overcoming the limitations of current proximity inducers requires optimizing cooperativity. Learn how enhancing target affinity can lead to smaller, more effective therapeutics with better safety profiles. |
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| "Ultra High” Potency Development And Manufacture | Case Study | Cambrex | A biotech with limited experience in the development and manufacture of high potency compounds sought to develop a process for producing a highly potent API used to treat an unmet oncology need. |
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