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A head-to-head comparison of spray-dried and jet-milled mannitol for respiratory delivery reveals opportunities and risks for designing a product based on each approach. This case study describes how to use risk assessments to inform engineering technology selection and illustrates how particle morphology affects aerodynamic performance.
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Lung cancer therapeutics are often administered indefinitely as maintenance treatments. Explore formulation and manufacturing considerations for development of dry-powder therapeutics for local treatment of lung cancer. Read how an approved drug — topotecan — is successfully formulated for DPI administration to the lung.
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The simultaneous spray drying of multiple ingredients is a powerful technique for making inhaled products with multiple actives. Examine how novel spray-drying techniques can help make these products a reality. Learn how a simultaneous spray-drying approach might be used to manufacture combination therapies to treat lung cancer.
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Inhaled formulations are traditionally prepared by micronization and blending, but many APIs are not compatible with milling, including biologics. Gain insights into a “simul-spray” process pioneering for combining small and large molecules into a single, atomized drug product for inhalation administration.
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