Simultaneous Spray Drying For Innovative Dry Powder Inhaler Combination Formulations

Source: Lonza

Spray drying is a particle engineering technique that can be used to manufacture dry powder inhaler formulations for pulmonary delivery. This webinar focuses on recent developments in spray drying technology that have allowed challenging combination formulations to be created. One of the examples which will be discussed is the generation of combination dry powder inhaler formulations of a monoclonal antibody (mAb) and three small molecule APIs in a single unit operation.

Combination therapies delivered to the lung by dry powder inhaler are an effective way of reducing the treatment burden on patients. Inhaled formulations are traditionally prepared by micronization and blending, but many APIs are not compatible with milling, including biologics. They might also require a higher dose than can be achieved with a micronize-and-blend approach. 

The simultaneous spray drying of multiple ingredients is a powerful technique for making inhaled products with multiple actives. This webinar examines how novel spray drying techniques can help make these products become a reality. 

Key Learning Objectives:

  • Understand applications and indications where dry powder inhaler combination formulations are desirable
  • Become familiar with the simultaneous spray drying process, and how it can produce challenging combination formulations
  • Learn how a simultaneous spray drying approach might be used to manufacture combination therapies to treat lung cancer
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