Application Note

Flexsafe® Pro Mixer: Fast, Flexible And Intelligent Solution For Buffer Preparation

Source: Sartorius

By Delphine Audubey, Adiba Ahmad, and Anilkumar Paramathma

Sartorius

Flexsafe® Pro Mixer is a unique single-use technology fitting all mixing applications from buffer and media preparations, downstream processes to final formulation. Flexsafe® Pro Mixer ergonomic design enables intuitive, modular and agile use to achieve fast installation and mixing operations. Additionally, the Flexsafe® film offers high standard quality attributes such as Biocompatibility, Integrity and Supply network.

This application study presents performance data of the Pro Mixer from 50 L to 1,000 L using five buffer solutions: Glycine buffer, Tris buffer, 20x DPBS, Sodium Citrate and Sodium sulfate | MES. These buffers are commonly used in different steps of biomanufacturing such as tangential flow filtration, pH re-equilibration, and final formulation. The powders used to manufacture those buffers are mainly sinking powders and some of them are high concentrated buffers.

The performances of the single-use mixing system are assessed using quantitative (conductivity and pH measurement) and qualitative (visual inspection) measurements..

VIEW THE APPLICATION NOTE!
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