Featured Articles

1. Toward A Gene Therapy Platform: What's The Best Format Of Tangential Flow Filtration (TFF)? 1/13/2025

   Evaluate TFF formats (hollow fiber and flat sheet) and membrane chemistries for AAv gene therapy processing, assessing performance, scalability, economy, and closed processing options.

2. Solvent-Free Purification Of D84-mer Oligonucleotide Using Capto™ PlasmidSelect Resin 1/13/2025

   Discover a solvent-free process using Capto PlasmidSelect and Capto Q ImpRes resins. They enable high-purity, scalable purification of long oligonucleotides, achieving more than 95% of full-length product purity.

3. Single-Step Purification Of A 21-mer Oligonucleotide Using Capto™ Q ImpRes Resin 1/13/2025

   Explore how the oligonucleotide therapeutics market is advancing with scalable solutions for high-purity purification, supporting global production of life-changing RNA therapies.

4. The Crucial Role Of Downstream Processing In Optimizing RNA-LNP Drug Development 8/28/2024

   Explore the key aspects of lipid nanoparticle (LNP) development, including the essential downstream processes of Tangential Flow Filtration (TFF) and normal flow filtration.

5. End-To-End Manufacturing Of Autologous CAR T Cell Therapies 6/13/2024

   Learn about a modular, functionally closed, end-to-end solution for the manufacture of autologous CAR T cell therapies.

6. Considerations For Developing The Recirculation/Perfusion Process 6/6/2024

   Learn about the recirculation and perfusion processes made possible by single-use, fixed-bed bioreactors designed for scaling up adherent cell culture processes.

7. Genomic Medicine Demands Manufacturing Innovation 5/28/2024

   The promise of novel therapeutic modalities can only be realized when effective science is paired with efficient manufacturing to provide cost-effective therapies to patients in need.

8. A Different Approach To Adeno-Associated-Virus (AAV) Clarification 5/10/2024

   Knowledge of the feed stream, process constraints, and goals, makes selecting depth and membrane filter combinations for preliminary bench-scale filterability studies possible.

9. Tips For Viral Vector Production 4/16/2024

   Learn about how meticulous purification optimization can maximize recovery and impurity removal by leveraging scalable downstream technologies to meet regulatory and process economy requirements.

10. What Is A Viral Vector? 4/16/2024

    Review a novel adenovirus production process that offers scalable, single-use equipment-compatible solutions, reducing production time and cross-contamination risks.