
ABOUT SCIEX
Advances in human wellness depend on the power of precise science.
At SCIEX, our mission is to deliver solutions for the precision detection and quantification of molecules, empowering our customers to protect and advance the wellness and safety of all.
SCIEX has led the field of mass spectrometry for 50 years. From the moment we launched the first ever commercially successful triple quad in 1981, we have developed groundbreaking technologies and solutions that influence life-changing research and outcomes.
Today, as part of the Danaher family of global life science and technology innovators, we continue to pioneer robust solutions in mass spectrometry and capillary electrophoresis. But we don’t just develop products. It is what we do together with our customers that sets us apart. That’s why thousands of life science experts around the world choose SCIEX to get the answers they can trust to better inform critical decisions. Decisions that positively impact lives.
We proudly stand behind our tagline: The Power of Precision.
CONTACT INFORMATION
SCIEX
1201 Radio Road
Redwood City, CA 94065
UNITED STATES
Contact: Robert Ellis
FEATURED ARTICLES
-
Here, electron activated dissociation (EAD) on the ZenoTOF 7600 system is used for the complete structural elucidation of glycerophospholipids, sphingolipids, and acylglycerols in a single experiment.
-
Fragmentation is required to provide structural information about metabolites during drug discovery. Here, two orthogonal fragmentation techniques are compared to determine the in vitro metabolism of the drug darunavir.
-
Post-translational modifications (PTMs) are important players in a diverse group of functions that include protein conformation and signaling. This application note studies the site-localization of malonylated peptides using the SCIEX ZenoTOF 7600 system.
-
In this technical note, we demonstrate parallel, highly reproducible capillary isoelectric focusing analysis using a multi-capillary separation approach to accelerate analysis time.
-
Explore how to achieve sensitive, high-resolution analysis of large oligonucleotides, with the opportunity to perform both qualitative and quantitative analysis in a single run.
-
Here a solution is presented to widely recognized challenges with ionpairing reversed phase liquid chromatography (IP-RP LC) through a novel microflow LC-MS strategy.
-
This technical note describes the identification, relative quantification and structural confirmation of the chain-shortened metabolites of a phosphorothioated oligonucleotide.
-
We demonstrate an easy sample preparation and labeling scheme is described using commercially available fluorescent tag which doesn’t require buffer exchange nor dye cleanup for the low level detection of AAV8.
-
We review a CE-SDS-LIF method for assessing the purity of AAV viral capsids utilizing FQ fluorescence dye labeling and LIF detector to provide an ultra-high sensitivity for in-process AAV product analysis with titer as low as 1X 1010 GC/mL.
-
We demonstrate the capability of the CE-SDS method for purity analysis of AAV viral proteins with easy sample preparation, excellent resolving power, good repeatability and linearity of absorbance response to sample concentration.
-
Presented here is an approach for the characterization of AAV capsid proteins and associated post translational modifications (PTMs) using a bottom-up approach.
-
This technical note describes the identification, relative quantification and structural confirmation of oligonucleotides and related impurities using molecule profiler software.
-
Learn about a new level in sensitivity for challenging analytes in matrix that opens doors for accurate bioanalysis and metabolism studies with specificity not achievable with orthogonal methods.
-
In this technical note, we describe the development of novel CE-LIF based methods for accurate determination of size purity of AAV genome.
-
Presented here is a streamlined approach for the determination of the intact molecular weight of viral capsid proteins from AAV8.
-
This technical note demonstrates a robust cIEF-based method for the separation and analysis of AAV full and empty capsids of different serotypes.
-
The key to achieving robust analytical results lies in the combination of sensitivity, selectivity, and specificity. Recent technological advancements enable the most demanding sample types and workflows.
-
Collecting quality MS/MS at high acquisition rates is key to achieving high numbers of peptide and protein identifications. This study investigates the impact of large sensitivity gain on identification rates.
-
Technical summaries and detailed protocols for purity testing, sizing, sequencing and expression analysis of oligonucleotide-based active agents as well as protein and lipid-based delivery systems.