News | September 3, 2019

WuXi AppTec Launches DNA Encoded Library (DEL) Service Package ‘DELight' To Expedite Early Drug Discovery

Shanghai and Boston, MA /PRNewswire/ - WuXi AppTec today announced its launch of DELight, a novel DNA Encoded Library (DEL) service package, providing cost-effective and efficient hit finding services to expedite early drug discovery and bring new medicines to patients faster.

DELight is WuXi DEL's self-serve product that gives researchers direct access to a collection of more than eight billion compounds. Through the DELight service package, WuXi will provide a DNA Encoded Library kit and a user manual/protocols document to the research organization. Upon receipt of the kit, the researcher will perform affinity selection according to the protocol and return the sample to WuXi. WuXi then completes analysis such as PCR amplification, qPCR determination, purification and NGS (Next Generation Sequencing). A summary report (excluding structural and DNA sequence information) will be provided back to the researcher, who will make informed decision on follow up actions based on the selection results.

Compared to traditional DEL services, DELight is a more convenient, efficient and economical service package, allowing researchers to perform their own affinity selection with minimum assay development and without disclosing target information.

"The launch of DELight can further enhance the application and development of DEL technology in the new drug discovery industry and provide strong technical support for customers to accelerate early drug discovery," said Xuanjia Peng, head of the WuXi DEL team. "DELight offers innovators and entrepreneurs an affordable and instant access to advanced DEL technology that can improve the productivity of new drug discovery and bring new medicines to patients faster."

The WuXi DEL platform now features 90 billion unique molecules covering major medicinal-chemically preferred cores, most of which are self-designed and custom-synthesized, making these libraries structurally diverse and chemically exclusive. Through evolutionary screening, the unique drug-like libraries expand the accessible number of drug candidates, leading to better and faster development of new medicines. So far, various targets from different classes have been screened and multiple nanomolar hits have been identified.

About WuXi AppTec
WuXi AppTec provides a broad portfolio of R&D and manufacturing services that enable companies in the pharmaceutical, biotech and medical device industries worldwide to advance discoveries and deliver groundbreaking treatments to patients. As an innovation-driven and customer-focused company, WuXi AppTec helps our partners improve the productivity of advancing healthcare products through cost-effective and efficient solutions. With industry-leading capabilities such as R&D and manufacturing for small molecule drugs, cell and gene therapies, and testing for medical devices, WuXi AppTec's open-access platform is enabling more than 3,600 collaborators from over 30 countries to improve the health of those in need – and to fulfill our dream that "every drug can be made and every disease can be treated." Please visit:

About WuXi DNA-Encode Library (DEL) Technology Service
WuXi DEL Technology Service provides customers with a cutting-edge hit identification and optimization platform using an affinity-based selection method against DNA-Encoded small molecule libraries. With operations in China, Europe and North America, clients range from small biotechnology companies to large pharmaceutical companies.

Source: WuXi AppTec

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