Newsletter | September 23, 2025

09.23.25 -- The Evolving Landscape Of Drug Discovery Services

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Webinar: Extrusion-Based ASD Scale-Up: Ensuring Performance Through Process Understanding

Boost your drug development success with Lonza’s upcoming webinar on amorphous solid dispersions (ASDs). Learn how hot melt extrusion (HME) can enhance bioavailability, cut costs, and scale efficiently—backed by real-world lab and pilot trials. Compare HME and spray drying while gaining exclusive insights into Lonza’s advanced capabilities and proven expertise in ASD manufacturing. Don’t miss it! Click here to learn more.

FEATURED EDITORIAL

AI Meets Aging: Inside The Longevity Revolution With Insilico Medicine

An interview with Alex Zhavoronkov, PhD. longevity and drug discovery researcher, founder, CEO and CBO at Insilico Medicine. Founded in 2014, Insilico Medicine is one of the earliest AI-driven biotech companies and one of the few who have pipeline drugs in Phase II trials.

 

INDUSTRY INSIGHTS

 

NIH:OVCAR-3 Human Ovarian Cancer Model

Review studies using the NIH:OVCAR-3 model of human ovarian cancer in the subcutaneous setting in NSG mice with multiple standard agents and vehicles. This model has shown reproducible growth.

 

Fluorescence-Based Technologies For Binding Affinity Studies

Reliable binding measurements drive research forward. Explore fluorescence techniques and optimal labeling strategies for sensitive, high-quality data crucial for discovery and cellular studies.

 

Unlocking miRNA Biomarkers With NGS And Digital PCR

Discover how next-generation sequencing and digital PCR enable miRNA biomarker discovery and validation. Learn best practices for sample prep, data analysis, and assay design.

 

A Changing Paradigm For Non-Rodent Species In Nonclinical Safety Studies

The choice of species for nonclinical safety studies is an important step in the drug development process. Check out this scientific journal which outlines vital considerations for species selection.

 

Design Of Experiments Approach To Enabling Studies For Process Validation

A recent project applied process improvement methodology to the process validation step that ultimately provided not only an optimized, robust process but also an economic advantage.

 

Rapid, Material-Sparing Feasibility Screening For Hot Melt Extrusion

Discover a screening process to quickly assess HME feasibility that yields more accurate predictions for API loading and degradation while saving material and time compared to traditional approaches.

 

Pre-Clinical Risk Assessment Of PCSK9 Guide RNAs

Learn how a comprehensive, variant-aware screening workflow for therapeutic gene editing can identify and nominate the most favorable guide RNAs for clinical development.

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The MASH therapeutic landscape is rapidly evolving, with Madrigal’s first approval paving the way for broader patient-centered solutions. The 9th MASH Drug Development Summit unites pharma leaders and pioneering biotechs to explore novel mechanisms, biomarker integration, and breakthrough therapies. Join 60+ experts from Eli Lilly, Pfizer, AstraZeneca, Takeda, and more to accelerate transformative treatments.

SOLUTIONS

Gene Optimization And Rapid, Reliable, Accurate DNA Synthesis

Scale Up Your Cell Therapy With Lipid Nanoparticles

Amorphous Solid Dispersions: Pre-Clinical To Commercial Capabilities