SynPhase Lanterns offer superior handling for solid phase combinatorial chemistry

Mimotopes Pty Ltd. (Clayton, Victoria, Australia) has introduced a new product line for solid phase combinatorial chemistry. Mimotopes' SynPhase Lanterns offer improved loading and kinetics compared with conventional solid supports, which the company says leads to better handling convenience and increased productivity.

Solid phase combinatorial chemistry systems must be simple to use, require little manipulation, and be flexible enough to cater for a wide range of synthesis techniques. SynPhase Lantern products offer a wide choice of handling methods, without the problems of filtration, weighing, and transfer associated with resin. A range of modular accessories allow for parallel array synthesis and the use of tagging techniques for split/mix methods. SynPhase Lanterns are fully compatible with most commercially available automated synthesis equipment. Access to a wide range of templates and chemistries are provided through a wide range of derivatized SynPhase lanterns or through user-prepared versions of solid bound linker.

SynPhase Lanterns are based on mobile polymers grafted onto rigid unreactive substrates. The grafted polystyrene surface, optimized for uniform reaction rates, is bound to a rigid polymer framework that enables reliable handling during all stages of synthesis. The unique "lantern" shape provides maximized surface area, free flow-through of reactants and rapid drainage of wash solutions. The high reproducibility of the grafting process ensures that batch-to-batch variation in loading is minimal.

SynPhase Lantern is offered in two sizes: L-Series Lantern (5mm diameter x 5mm high) features a loading of 15 mol, while the D-Series (5mm diameter x 12.5mm high) sports 35 µmol loading. The SynPhase Lanterns operate over a wide temperature range (-80 to 100°C), with minimal swelling in most common solvents, and are stable to agitation and ultrasonics.

For more information: Lindsay Moore, Product Manager, Mimotopes Pty Ltd., 11 Duerdin St., Clayton Victoria 3168 Australia. Tel: +61 3 9565 1115. Fax: +61 3 9565 1199.

Edited by Angelo DePalma
Managing Editor, Drug Discovery Online