Selvita Announces First Patient Dosed In Phase I/II Clinical Trial Of SEL24 In Acute Myeloid Leukemia

Selvita, a clinical stage drug discovery and development company focused on innovative medicines for patients with blood cancers, announced recently that the first patient was dosed with SEL24 in a Phase I/II clinical trial, for acute myeloid leukemia (AML).

SEL24 is a Selvita-developed first-in-class dual PIM/FLT3 kinase inhibitor with a unique activity profile in oral formulation. It is intended for the treatment of patients with relapsed/refractory (R/R) AML. The major goal for treatment of R/R AML is to achieve remission or to significantly prolong life, with acceptable quality.

This Phase I/II study is the first clinical trial initiated by Selvita, demonstrating the significant progress achieved in the Company's pipeline of proprietary product candidates. The SEL24 clinical program is anticipated to provide important safety, tolerability and biomarker efficacy data for SEL24 to support its clinical potential in AML, other hematological malignancies as well as solid tumors.

"I am both proud and appreciative of the Selvita team and our clinical investigators in the USA, who have helped to make this key milestone possible" said Krzysztof Brzozka, Chief Scientific Officer at Selvita. "This is an important step toward Selvita’s biggest goal - bringing to market a potentially life-saving treatment for patients suffering from aggressive AML."

The preliminary data established in the first part of the study will include the recommended dose and evaluation of SEL24 pharmacokinetic profile.

Selvita Oncology Pipeline
In its internal research and development efforts, Selvita focuses on oncology. The company’s most advanced R&D program is SEL24, a dual PIM/FLT3 kinase inhibitor currently in Phase I/II clinical study. The second most advanced program is SEL120, a first-in-class small molecule inhibitor of CDK8 with potential use in hematological malignancies, colorectal cancer and breast cancer. Several Selvita programs have been partnered with Merck/EMD Serono, H3 Biomedicine/Eisai and Nodthera/Epidarex. Selvita Early Discovery programs include: Immunooncology platform, Eptheron – an oncology platform with an aim to develop novel molecules specifically targeting certain epigenetic and metabolic abnormalities in cancer, as well as an early discovery stage immunometabolism program and project targeting novel kinase targets.