E-Book | July 19, 2021

Intensifying Upstream Processing - Implications For Media Management

Source: Sartorius
Sartorius

Biopharmaceutical development and production require the investment of significant time and resources. Manufacturing procedures must be efficient, robust, and productive to minimize failure risk and ensure targets are met.

Operational modifications that intensify upstream processing allow manufacturers to maximize their output without significantly altering their production approach. Effective process intensification (PI) strategies can enhance several measures of efficiency, including faster drug development, increased productivity of GMP manufacturing, reduced footprint, enhanced flexibility, and improved quality. The best PI approaches will combine and deliver several of these benefits, allowing biologics manufacturers to remain competitive. However, adopting (PI) might introduce some additional challenges, such as effectively managing increased media volumes.

Here, Sartorius provides biotherapeutic developers with the tools and knowledge to confidently explore their intensification options. First, we discuss the benefits of implementing PI before exploring the potential implications on media management. We then outline the value in conceptual design to assist with the logistics of the media journey. Finally, we review the feasibility of implementing different PI scenarios in both existing and new facilities.

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