In the biopharmaceutical industry (biopharma), process data is used in many ways throughout process development (PD) and the different production phases. But the pieces of equipment are often connected only by process; that is, the bioprocess material passing between each of them. Often this connection is discontinuous, meaning that equipment is controlled on an instrument level, which results in islands of automation. This article outlines how connectivity and a comprehensive automation solution can ease technology transfer and scaling from PD to final manufacturing scale. Suitable automation solutions also help maximize both manufacturing efficiency and facility utilization.