06.11.24 -- Gene Therapy: How Should We Approach Benefit And Risk?

Everything from glass or plastic bottles to the ink used in labels can leach unwanted contaminants. The first challenge chemists address is to narrow the focus on the most likely suspects.

Gene delivery platforms must support a diversity of genetic engineering strategies for genomic medicine development. Learn how lipid nanoparticles can accelerate development from discovery to scale-up.

In this study, we used mechanistic modeling to investigate how AAV-resin interactions are affected when MgCl₂ is used as an elution additive.

This paper presents three approaches to address poor solubility in organic solvents for spray drying as well as case studies outlining their successful application during development.

Here, we present an example of a gene therapy bioprocess in which an AAV8 upstream process was optimized to enhance downstream process performance.

Examine the methods used to evaluate, design, and implement solvent recovery processes, a crucial way to achieve significant reductions in carbon emissions.

End-to-end development and manufacturing can simplify and accelerate the development pathway, even for APIs with challenging properties, such as low aqueous solubility and poor bioavailability.