5 Types Of Formulation Excipients And How They Impact Biologics Stability

By Stefanie Kall

Buffer optimization in pre-formulations research is crucial for the long-term stability of biologic candidates, going beyond mere pH and salt concentration of the solution. This involves the use of excipients or additives such as adjuvants, surfactants, amino acids, sugars, and polyols. Many different excipient types enhance immune response and long-term biologic stability. Review how each excipient stabilizes biologics in unique ways and are important considerations in the pre-formulation stage. Tools like the Prometheus Panta aid researchers in assessing how these components contribute to the stability of their therapeutics, thus speeding up the buffer optimization process.