Newsletter | April 23, 2024

04.23.24 -- Drugging The Undruggable: Strategies And Future Directions

FEATURED EDITORIAL

Drugging The Undruggable: Strategies And Future Directions

Progress with PROTACs and molecular glues hasn’t come without challenges, particularly in identifying the right chemistry starting point for drug development — a process known as hit discovery. This article looks at the role of CRISPR, screening assays, and more.

INDUSTRY INSIGHTS

Process Re-Design For Sustainability In Small Molecule Manufacturing

Review the optimization of the manufacturing process of a pharmaceutical intermediate and discover how yield can be improved substantially via suitable reaction engineering.

The Colloidal Particle Adsorption (CPA) Model In IEX

Learn about an adsorption isotherm class that is based on a colloidal description of proteins and achieves increased accuracy at high column loading in IEX modeling.

A Smart, Data-Driven Approach To Formulate Biotherapeutics For PFS

Explore a unique model to predict injection force designed to decorrelate factors linked to formulation development and the ones linked to container and delivery device selection.

End-To-End Development And Manufacturing: Small Volume Products

To meet ambitious orphan drug development timelines, CDMOs must be able to scale quickly to progress from early clinical development to validation and commercial launch.

MOST POPULAR NEWS

Scripps Research Chemists Develop An Easy Method For Making Saturated Heterocycles

Invenra Inc. Announces A Strategic Research Agreement With Astellas Pharma

Scientists Find New Ways To Convert Inhibitors Into Degraders

Global Collaboration To Combat Chronic Lung Infection

Stealth Biotherapeutics Announces FDA Acceptance Of NDA For Elamipretide

Improving Drug Development With A Vast Map Of The Immune System

A New Generation Of Antidepressant Drug Precision Treatment Based On AI Technology

CureVac & MD Anderson Enter Strategic Collaboration To Develop Novel Cancer Vaccines

AI Speeds Up Drug Design For Parkinson’s Ten-Fold

Tr1X Announces FDA Clearance Of First IND Application For TRX103

Shorla Oncology Announces FDA Filing Acceptance Of NDA To Treat Certain Forms Of Leukemia

SOLUTIONS

CESS Technology