Application Note

Best Practices For Successful Filter Integrity Testing Using The Water Intrusion Test (WIT) Method

Source: Cytiva
Lab Testing GettyImages-1097343012

The water intrusion test (WIT) is widely used in the pharmaceutical industry to test the integrity of vent filtration for holding tanks and bioreactors, autoclave and lyophilizer vent filters. Explore the collected best methods/practices to give filter end users the best possible chance of performing a successful WIT along with the factors that influence the WIT, the most common reasons for “false failure” results associated with the WIT, and how to overcome them.

Following these methods/practices will provide the end user with the most advanced way to test critical gas and air vent filters to ensure the highest process safety and to demonstrate compliance with regulatory requirements according to FDA and European Guidelines.

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