Case Study

Advanced Bioscience Laboratories Inc. (ABL) Scaled Up Lentiviral Production

Pall image 3 450 300

The use of lentivirus vector in the production of CAR-T and gene therapies is increasing. Frequently, lentiviral vector production is conducted in multi-layered flatware vessels or fixed-bed bioreactors like the popular iCELLis bioreactor. The iCELLis bioreactor system is a fixed-bed bioreactor comprised of carriers made of non-woven medical-grade polyethylene terephthalate (PET) fibers. The iCELLis bioreactor provides optimal growing conditions for adherent cells employing a closed, automated, single-use platform.

A recent experiment was conducted by Advanced BioScience Laboratories and Pall to scale up a lentivirus process from the iCELLis Nano bioreactor to the iCELLis 500+ bioreactor with very little development work. The goal was to produce lentiviral titers in the iCELLis 500+ bioreactor greater than or equal to the iCELLis Nano bioreactor and to use nutrient and metabolite analysis to determine if cell growth is similar between the two.

VIEW THE CASE STUDY!
Signing up provides unlimited access to:
Signing up provides unlimited access to:
  • Trend and Leadership Articles
  • Case Studies
  • Extensive Product Database
  • Premium Content
HELLO. PLEASE LOG IN. X

Not yet a member of Drug Discovery Online? Register today.

ACCOUNT SIGN UP X
Please fill in your account details
Login Information
ACCOUNT SIGN UP

Subscriptions

Sign up for the newsletter that brings you the industry's latest news, technologies, trends and products.

You might also want to: