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Current methods for measuring empty to full (E/F) capsid ratios tend to be costly and time-consuming, and they face several other limitations, making it challenging to identify an ideal, cost-effective solution. Discover a biosensor designed to provide the rapid, real-time, high-throughput measurement of AAV capsid titer in samples throughout the workflow.
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Learn about a rapid, high-throughput method that determines the E/F ratio in the AAV drug product with a single measurement, avoiding the compounded errors inherent in methods that rely on two separate measurements for capsid titer and DNA content. This method is well-suited for screening crude and purified AAV samples.
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Accurate measurement of viral capsid concentration is critical for successful AAV vector production at an industrial scale, both in upstream and downstream bioprocessing. Leveraging an innovative BLI platform can streamline the measurement of AAV capsid titer, expediting gene therapy development and enhancing quality control processes.
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Examine the performance of a biosensor for AAV capsid titer measurement that allows for the quantitation of ten different serotypes, is compatible with various sample matrices in upstream and downstream processes, and significantly lowers the cost per measurement as it can be reused up to twenty times.
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Gain insight into how a high-throughput capsid assay for rapid AV quantification was developed using an innovative Bio-Layer Interferometry (BLI) platform, offering high precision and reliability. This new assay can be applied as a standardized method for at-line viral titer quantification in bioprocess settings.
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Unveiling The Biophysics Behind Bio-Layer Interferometry
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Bio-Layer Interferometry (BLI) allows users to perform label-free biomolecular interaction analysis in real time. BLI biosensors provide a fluidics-free design facilitating scalability in throughput and the capability to assess interactions from crude, unpurified samples for faster decision-making. Explore BLI and the advantages of utilizing a proven BLI platform.
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Biosensors For The Quantitation Of AAV Capsids
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AAV capsid titer is a critical quality attribute that must be monitored throughout process development and the production of AAVs. Watch to see how two different approaches compare in the development of gene therapies, and learn about a solution that provides a rapid, direct, and high-throughput approach for the quantitation of AAV capsids.
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