Medicinal Chemistry and Drug Discovery Services

SCYNEXIS Medicinal Chemistry and Drug Discovery: Selected Expertise Areas

SCYNEXIS Medicinal Chemistry and Drug Discovery: Core Capabilities

• Multiple Candidate Selections
• Lead Optimization Experts
• Lead Generation Libraries
• Virtual Screening
• Pharmacophore Design
• QSAR Analysis
• Structure Based Design
• Rapid ADMET-PK Profiling

The complex process of transforming a hit into a clinical candidate requires a broad range of technical skills and capabilities. SCYNEXIS seamlessly integrates Medicinal Chemistry, Computational Chemistry, Analytical Chemistry, ADMET-PK and Bioanalytical Chemistry into SCYNEXIS Research Teams that focus these disciplines to meet very specific, timeline-driven project demands. SCYNEXIS supports these efforts with HEOS®, a secure, web-based data and information management system.

SCYNEXIS Drug Discovery and Development – Research Teams

The Research Team leaders are knowledgeable scientists with years of industry experience and keen project and program management skills. More than half of our medicinal chemistry team holds Ph.D. degrees. Above all else, they are experts at coordinating and communicating key activities while effectively driving the necessary resources to achieve success. SCYNEXIS Research Teams include fully-integrated ADMET-PK scientists to provide customers with fast and efficient medicinal chemistry decision support for rapid hit seeking, H2L, lead optimization and candidate selection. Our Research teams act as an assimilated extension of our clients' R&D organizations. The teams are enabled with SCYNEXIS' powerful proprietary technologies such as HEOS® Software Suite and MEDCHEM-FACTORY®.

SCYNEXIS Medicinal Chemistry and Drug Discovery: Selected Achievements

• Multiple antifungal candidate selection programs leading to milestone payments and potential royalties
• Optimized a non-bioavailable natural product into an orally effective drug candidate
• Advanced a hit (5 micromolar) to a 20 nanomolar enzyme inhibitor in a four-month time frame
• Addressed and improved the stability and solubility liabilities in a series leading to an accepted backup compound

The SCYNEXIS Advantage:

• HEOS® (Hit Explorer Operating System):
  Comprehensive, web-based drug discovery information management software.
• MEDCHEM-FACTORY®:
  High-throughput synthesis and purification capable of delivery 60,000 compounds/year
• Computation Chemistry Expertise:
  Predictive physiochemical properties, homology modeling and receptor docking and QSAR.
• ADMET-PK Expertise:
  Fully-integrated team to determine in vitro ADME, bioavailability and full pharmacokinetic profile.

About SCYNEXIS:
SCYNEXIS is a premier drug discovery and development company offering fully-integrated contract research and manufacturing services including Medicinal Chemistry & Drug Discovery, In Vitro Pharmacology, ADMET-PK/Bioanalytical, Process Chemistry & cGMP API supply. SCYNEXIS is both FDA and DEA registered and headquartered in Research Triangle Park, NC – www.scynexis.com