Devoting early-phase resources for solid form understanding and screening during a drug’s development lifecycle is critical. Abhijeet S. Sinha, Manager of Solid Form Services (SFS), addresses attendee questions from a recent webinar on how to nominate a lead form, when to utilize a salt screen, and other solid form strategies.
Solid form screening encompasses the search, preparation, and characterization necessary to identify, isolate, and ensure confidence in the stability and downstream manufacturability of a lead form. In many ways, this process serves as the bridge between drug substance and drug product for new chemical entities.
In this webinar, we discuss the role of solid form services in helping meet the accelerated timelines of the drug development lifecycle and share examples of robust workflows for fast and thorough solid form screens. A case study reviews the polymorph screen of a late-stage API focusing on monotropic vs enantiotropic polymorphs.
Several factors are driving the need to reduce development time. Explore an integrated package that offers a combination of targeted testing and basic scientific principles to accelerate development of a preferred synthetic route, a progressible solid form, and a commercially viable formulation in early drug development.
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