Single-pass tangential flow filtration (TFF) is revolutionizing how TFF is implemented in biotech, vaccine, blood plasma and other applications. Pall is now making it even easier to implement this breakthrough patented technology into your process. As with the original Cadence single-pass TFF module, the new Cadence Inline Concentrator allows direct flow-through in-process volume reduction and can be implemented into a process system or operate as a stand alone unit.
This exciting new technology leads to economic and practical benefits, including:
- Ability to couple the concentration of product before or after other Downstream Processing (DSP) steps, consequently optimizing other steps and reducing in-process pool tank volumes.
- Continuous processing in DSP
- Easy integration of the assembled module, allowing plug and play.
- Potential reduction of product damage or aggregation due to reduced residence time and shear exposure.
The preassembled Inline Concentrator modules do not need a holder. Once the feed port is connected to a pressurized feed source, the module is ready for use. The built-in resistor in the retentate manifold eliminates the need for downstream instrumentation and allows volume reduction of 2 to 4X (or higher), depending on the application. Pall can provide tubing sets to ease the testing and implementation of the Cadence Inline Concentrator.
Using Cadence Inline Concentrator with Delta membrane, the innovative benefits of single-pass TFF technology are enhanced by the proven high flux, high selectivity, and low protein binding attributes of Delta regenerated cellulose membrane.