About SCYNEXIS

SCYNEXIS
SCYNEXIS delivers integrated, efficient and innovative drug discovery and development solutions to our global health and pharmaceutical partners. Our record of success is exemplified by the delivery of 11 pre-clinical drug candidates over the last five years. Milestone payments have resulted as these compounds progressed through development at our partners.

Our expertise is offered on a fee for service basis or may be conducted in a shared risk arrangement. SCYNEXIS' teams are tailored to be especially effective in moving customer projects from concept to clinic, utilizing powerful proprietary technologies such as the HEOS® Data Management and Collaboration Software Suite and the MEDCHEM-FACTORY® High-Throughput Synthesis and Purification Platform.

Our fully-integrated contract research solutions include medicinal chemistry, advanced biological screening, in vitro pharmacology and ADMET, DMPK, bioanalytical and analytical chemistry, process chemistry, and cGMP manufacturing. The SCYNEXIS process chemistry department recently passed a general inspection and pre-approval inspection (PAI) by the FDA in support of a customer's NDA.

Founded in 2000, SCYNEXIS is located in Research Triangle Park, N.C. and occupies more than 120,000 sq.ft of laboratory and office space strategically located in close proximity to RDU International Airport, GSK, IBM, and Cisco and central to the campuses of UNC Chapel Hill, Duke University and NC State University. SCYNEXIS is registered with both the FDA and DEA. For more information, please visit www.scynexis.com.

Our expertise areas include:

• Fully-Integrated Drug Discovery & Development Programs
• Contract Research & Development Capabilities
• Chemical Process Development & GMP Manufacturing
• Medicinal Chemistry & Lead Optimization
• Bioanalytical & ADMET Services
• Analytical Method Development & Validation
• HEOS Data Management & Collaboration Software

Click Here To Download:
•SCYNEXIS Capabilities Overview

Contract Research & Development Capabilities

Medicinal Chemistry & Lead Optimization

SCYNEXIS' medicinal chemistry group has a reputation equaling the best in the industry. Our team has the size and experience to handle projects of any complexity in a wide range of therapeutic areas. The Research Team leaders are knowledgeable scientists with years of industry experience. They coordinate and communicate key activities and drive resources to achieve success. The teams are enabled with SCYNEXIS' powerful proprietary technologies such as KIT™ Kinase Inhibitor Technology , HEOS® Software Suite and MEDCHEM-FACTORY®.

• HEOS® (Hit Explorer Operating System): Comprehensive web-based chemical information management software
• ADME/PK: Bioavailability, stability and Cyp450 information is available from our in-house capability
• KIT™ (Kinase Inhibitor Technology): Leverages structural information to define binding modes
• Computational Chemistry: Predictive physiochemical properties, homology modeling and receptor docking, QSAR
• MEDCHEM-FACTORY®: High-throughput synthesis and purification

Chemical Process Development & GMP Manufacturing

The SCYNEXIS Process Development team consists of approximately 25 scientific experts with an average of 20 years of industry experience. 12 of the team members hold Ph.D.'s and we maintain an even balance between process and analytical team members.

cGMP Manufacturing Suites & non-GMP Kilo Facilities:

• 3 separate GMP Suites
• Controlled access, dedicated air handling
• GMP Reactors: 25 L to 200 L QVF glass fixed reactors
• Huber chillers/heaters
• QA Audited, Expecting PAI in 2009
• Versatile non-GMP facilities
• Non-GMP Reactors: 20 L to 200 L QVF glass fixed reactors
• 6" Biotage chromatography systems

SCYNEXIS' Process Chemistry team has outstanding analytical support. We have in-house 400 and 500 MHz NMRs, LC-MS and LC-MS/MS, FT-IR, HPLC, GC, K-F, TOC and dedicated experts to assist in method development, validation and impurity identification.

Bioanalytical & ADMET-PK Services SCYNEXIS provides rapid generation of reliable ADMET and pharmacokinetics (PK) on compounds with a focus on lead optimization integrated with medicinal chemistry teams. SCYNEXIS rapidly screens for properties including metabolic stability (complemented with specific CYP450 assays), permeability, transporters, protein binding and cytotoxicity to prioritize and optimize lead series based on ADMET properties. Secure timely web-based data exchange (HEOS®).

HEOS® Data Management & Collaboration Software

HEOS® suite is a comprehensive web-based Drug Research information management software that supports geographically distributed scientists and facilitate collaboration.

HEOS® is seamlessly integrated to "best" scientific expert software currently used in the Pharmaceutical Industry. It allows complex data (biology, chemistry, analytical, safety, PK...) to be exchanged, consolidated and shared rapidly and securely across multi-sites worldwide. It provides powerful searching capabilities to combine substructure and biological criteria, interactive SAR capabilities and decision tools to scientists and management.

Data Management:

• Comprehensive acquisition, organization and display of various types of information relevant to Drug Discovery projects: chemistry, analytical, biological assays, animal assays, ADME, Toxicology, Pharmacokinetics, etc.
• Powerful chemical-biological searching capabilities, including substructure searching
• Interactive SAR capabilities
• Flexible export to third-party software such as SpotFire for further data analysis

Collaboration:

• Secure access through a web interface with access-control to the data
• Easy publication of results from each project member
• Share decision-making reports
• Securely exchange key project documents