DRUG DISCOVERY FEATURED ARTICLES & APPLICATIONS

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  Imaging And Analysis Of A High Density Cell Migration Assay

  Complex biological or environmental signaling events can lead to cell migration, the movement of cells from one location to another. The migration of cells commonly occurs during both normal biological processes such as the development of an organism or marking pathological events such as cancer metastasis. Automated processes in higher density formats improve throughput greatly increasing the usefulness of performing migration assays at a larger scale. This study evaluated the use of a high density cell exclusion assay in 384- well format for investigation of cell migration using a cell line stably expressing green fluorescent protein (GFP).

• Getting The Most Out Of Your Viral Clearance Study

  By John Zehmer, PhD, Senior Scientist and Study Director at BioReliance

  Conducting a viral clearance study is an important step on the road toward getting your biomolecule into the clinic and on its way to becoming a drug. However, since most companies do not have the systems in place to support a regulated virological study of this kind, this will likely mean engaging a contract research organization (CRO) as a partner. The keys to meeting your goals are solid planning and good communication between your group and your CRO partner. This article provides a high-level review of these processes and will aid in planning for a successful study.

• Tools for the Design of Vaccines to Help Reduce Clinical Failure

  If you are involved in the pharma industry, then you are interested in saving lives. In the area of preventative medicine, therapeutic vaccines have proven to have a tremendous impact on the ability to save millions of lives. Similar to pharmaceuticals, vaccine development can take over 10 years and less than 10 percent of candidates reach commercialization. Reducing the cost of failure and increasing the chances of clinical success for vaccines is beneficial to both the pharma industry and those being treated for or protected from disease.

• Patheon Surfs Outsourcing Waves And Scoops Up Gallus Along The Way

  Jim Mullen, CEO of Patheon parent company DPx Holdings B.V., is at it again.

  On the heels of my three-part series with Mullen on the details behind the springtime merger of his company and the pharmaceutical products division of Royal DSM, he has made his next move.

  This time it is a strategic entrée into the U.S.-based market for biologics services via an acquisition of privately held Gallus BioPharmaceuticals. With Gallus, Patheon adds new capabilities at well-established sites with name-brand clientele, in St. Louis, Mo. and Princeton, N.J., to its global locations in Groningen, the Netherlands and Brisbane, Australia.

• Systematic Method Development Of UPC2 Conditions Using Opioid Drugs

  This application note uses a panel of natural and synthetic opioid drugs to demonstrate the use of a systematic screening strategy for UPC2 method development. By Jonathan P. Danaceau, Kenneth J. Fountain, and Erin E. Chambers, Waters Corporation

LATEST NEWS

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  New 50 Microliter Electronic Pipettes

  INTEGRA has expanded its popular VIAFLO II electronic pipette range. Often requested by users of PCR applications, the new 50 µl models perfectly fill the gap between the 0.5-12.5 µl and  5-125 µl ranges.

• PTC Therapeutics Begins Rolling NDA Submission To The FDA For Translarna To Treat Duchenne Muscular Dystrophy
• MRA Applauds Latest Melanoma Drug Approval
• Bio-Path Holdings To Initiate Development Of Liposomal Bcl-2 In Follicular Lymphoma
• Harbour Antibodies Announces First U.S. Patent For Novel Transgenic Mouse Antibody Technology For Next Generation Therapeutic Antibody Discovery

FEATURED PRODUCTS AND SERVICES

Resins for Solid Phase Chemistry

TentaGel and Polystyrene resins were designed for solid phase chemistry (combinatorial chemistry, library generation, peptide and oligonucleotide synthesis)

Drug Release & Stability Testing

When you're this close to bringing your product to market, Patheon's reliability is a valuable asset. What's more, we will conduct these tests for you at multiple sites – redundancy that can shield you from any risk.

Automated Colony Counter

Qcount is an automated colony counter that breaks through the limitations of ambient lighting and overlapping colonies to give sharp, error-free plate counts quickly...

Synopsis Scientific Systems Ltd.,

Synopsys Scientific Systems Ltd., a wholly-owned subsidiary of Pharmacopeia, Inc., provides high-quality scientific information products and services

Laboratory Refrigerator/Freezer

The Model RCRF252A14 25-cu-ft laboratory refrigerator/freezer combination is a two-door unit that features a ± 4°C refrigerator cabinet, a –15°C freezer cabinet, and forced air circulation...

NanoFlow Fluid Controller

The NanoFlow Fluid Controller offers nanoliter control of the fluid in experimental chambers or cells...

ARCHIVED NEWSLETTER

• 01.02.15 -- Novogen Announces Breakthrough Discovery In Treatment Of Melanoma
• 12.05.14 -- Researchers Discover Potential New Treatment Method For ALS
• 11.07.14 -- New Research In Pharmacologic Decision-Making In Treatment Of Focal Epilepsy
• 10.03.14 -- Scientists Develop Protein 'Map' For Identifying New Cancer Drugs
• 09.05.14 -- FDA Breakthrough Therapy Designation For NUPLAZID For Parkinson's Disease Psychosis