06.16.22 -- Rethink Genome Editing of CAR T Cells: From Discovery to Scale-Up

The demand for novel cell and gene therapies continues to grow; however, there are many challenges with current genetic engineering methods. Read this article to learn more about the different delivery technologies and how they are used for cell and gene therapies. 

Gene delivery platforms need to support a diversity of genetic engineering strategies for the development of genomic medicines. Read more about how lipid nanoparticles can accelerate development from discovery to scale-up. 

Read this article to learn about the potential technological solutions to key challenges in developing genomic medicines and realizing their full potential. 

Explore this application note to learn more about how to reproducibly create homogenous mRNA-LNPs, including a detailed case study on CRISPR/Cas9 knockout of the T-cell receptor for allogeneic CAR T-cell therapy.

Extra-hepatic delivery of genomic material remains a key challenge to discover novel therapies. Watch this short webinar by Dr. Dan Pier, professor and director, Laboratory of Precision NanoMedicine, Tel Aviv University, to learn more about gene silencing, activation, and modification beyond the liver.