11.02.21 -- Researchers Invent Chemical Reaction That Could Accelerate Drug Discovery

As the field of biologics increases its focus on identifying new diseases to target, novel constructs to treat those diseases, and innovative administration devices that include self-administration technologies to improve compliance and patient quality of life.

This white paper discusses the importance of understanding how critical process parameters can impact a product’s critical quality attributes, and how a systematic approach with validated SPR assays can help in this respect.

Overexpression of proteins has enabled access to highly purified proteins in large quantities for research and increasingly for medical purposes. However, the clarification process can be quite cumbersome, especially during early discovery, when working with multiple cultures of relatively small culture volumes. 

Breakthrough therapy designations and other expedited regulatory reviews enable more innovation on shorter timelines to the clinic and commercialization, but they require careful navigation.

Explore two case studies where lung cancer therapies were delivered to the lung by dry powder inhaler in a rat model and evaluated for efficacy. The results confirmed that local delivery is a promising route to treat lung cancer.