White Paper

Quality Matters – SEC Analysis For Antibody Aggregates

Source: Cytiva

By Jon Lundqvist, R&D scientist

Superdex 200 Increase column Lot to lot reproducibility_450x300

What factors affect column reproducibility?

Size exclusion chromatography (also known as gel fitration) is a well-established protein analysis method in drug quality control (QC). SEC aggregate analysis is a standard method for analysis of impurities such as mAb aggregates, which negatively affect the quality of protein-based drugs.

Multiple factors affect the performance of your column, the most important being the quality of the chromatography resin and the column packing procedure. However, there are other factors you may need to consider for the reproducible performance of your column.


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