Application Note

Production Of In-Specification Buffer On Demand For Batch Processes

Source: Cytiva
Allegro Connect buffer management system.jpg

The Allegro Connect buffer management system (BMS) has the capacity to dilute in-line up to six different buffer concentrates, in-specification and on-demand for connected downstream process (DSP) operations. The system is used and connected in a one-to-one fashion with any DSP unit and works via process buffer level control to initiate or stop buffer production as needed. For automated control, the Allegro Connect BMS can operate either as a stand-alone unit or as a slave to a compatible DSP system (master unit). The in-line dilution of each concentrate is controlled via a proportional–integral–derivative (PID) controller utilizing buffer conductivity measurement to adjust the concentrate pump flow rate as necessary, enabling the dilution to remain within a given tolerance. Additionally, continuous in-line buffer pH measurement is taken to confirm the correct buffer is being produced.

In-line dilution conductivity and pH performance data generated from a typical application test with the Allegro Connect BMS is presented here to show the capability to successfully produce process buffers within the acceptable tolerances. This was completed using both constant speed and level control automated in-line dilution at dilution factors ranging from 5x to 20x.


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