05.10.22 -- Optimizing Process Efficiency In Upstream Manufacturing

Increasing the integration of upstream and downstream processing and moving toward increased automation results in greater optimization of process efficiency — a key goal for biopharma production.

Learn about a new level in sensitivity for challenging analytes in matrix that opens doors for accurate bioanalysis and metabolism studies with specificity not achievable with orthogonal methods.

Everything from glass or plastic bottles to the ink used in labels can leach unwanted contaminants. The first challenge chemists address is to narrow the focus to the most likely suspects.

As the industry looks forward, key decision makers in pharma and biotech companies were surveyed to assess their views on undertaking regulatory processes virtually.

Centrifugation and filtration have been widely accepted as techniques required for clarifying complex cell cultures to recover extracellular proteins such as monoclonal antibodies (mABs). Read an alternative to the use of centrifugation/filtration/flocculation to clarify mammalian cell cultures, and an assessment of newly developed AcroPrep 24-well clarification and sterilization plate and AcroPrep 24-well sterilization plate for clarification of mammalian cell cultures (2 to 26 x 106 cells/mL) and recovery of proteins present in the supernatant.

This infographic explores the five actions that biotech companies should know when establishing their cell line development processes for commercialization of a biological product.

We discuss three enabling technologies designed to improve drug solubility in organic solvents for spray drying and define the advantages and risks of each technology.

Explore the needs of more complex candidates, through case studies that demonstrate the range of expression capabilities across mammalian and microbial derived molecules.