Newsletter | August 22, 2019

08.22.19 -- Novel Analytical Techniques For Monoclonal Antibodies

 
Novel Analytical Techniques For Monoclonal Antibodies
 

With the rising interest in biopharmaceuticals, drug developers need to quickly understand and evaluate the binding of therapeutic antibodies to Fc receptors. Learn how a new analytical testing panel that uses an Octet-based Fc receptor panel may help developers achieve a faster assessment of monoclonal antibody functionality — well before the final molecule is selected.

Optimizing Titer And Use Of A Specific Enzyme For Generating A Fully Processed Antibody
 
The number of more complex biopharmaceuticals in development continues to increase and some of these include molecules that require multiple proteins to be expressed at differing ratios to produce the correct biopharmaceutical. In this article, the authors outline cell-line development and process scale-up for an antibody program in which the antibody requires additional processing by a site-specific enzyme for correct functionality.
Case Study For Evaluation Of The 3M Emphaze AEX Hybrid Purifier Involving Low Isoelectric Point Target Proteins
 

The 3M Emphaze AEX Hybrid Purifier is a novel purification tool that utilizes a Q-functional hydrogel and 0.2 µm membrane to reduce impurities in a biopharmaceutical downstream process. This study involved a design of experiment (DoE) approach to investigate the effects of pH and conductivity on the turbidity, yield, and impurity clearance of the Emphaze AEX Hybrid Purifier and the efficiency of the subsequent protein capture step. 

Solution
Comparator And Marketed Drug Sourcing Solutions
 

Catalent in-house pharmaceutical sourcing specialists utilize a global network of leading manufacturers, wholesalers, and carefully selected QA-qualified healthcare professionals to provide cost-effective access to virtually any product. When you use Catalent for pharmaceutical sourcing you get a global distribution network that can deliver what you need, where you need it, and when you need it. Always in the right condition.