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As the field of biologics increases its focus on identifying new diseases to target and novel constructs to treat them, innovative administration devices are once again in the spotlight.
Antibody-drug conjugates' manufacturing supply chain contains five different technologies with specific asset needs: monoclonal antibody, cytotoxic payload, linker, bioconjugation, and fill/finish.
Application Note |
By Sarat Bimanadham and Nadia Kadi,Pall Corporation
In this report, we analyze the quality and quantity of gDNA as well as RNA from S. cerevisiae with Pall NAB Nanosep centrifugal devices in comparison with a renowned commercial brand.
Size-exclusion chromatography (SEC), also known as gel filtration, can be used for preparative and analytical studies of your protein. But how do you know which parameters give you the best resolution of your protein mixture?
Early planning for scale-up and biologics license application activities can maximize your chances of success by allowing sufficient time to develop launch options and prevent costly delays and setbacks.
Cost efficiencies and expertise again go hand in hand, with companies often outsourcing or partnering primarily to gain access to manufacturing know-how.
Infrastructure and expertise cover the sweet spot for producing the small-to-midsize batches needed to meet industry demands for PDFs and orphan drugs, and also extend to large-scale manufacturing.
To fully appreciate the work Pyxis Oncology is doing in its development of site-specific ADCs under the leadership of Lara Sullivan, M.D., you need to understand the work that shaped her leadership style. On the Business of Biotech, Dr. Sullivan shares the science and technology driving progress at Pyxis, and also serves up a master class on change management, honed during her tenure managing high-stakes product portfolios at Pfizer. Listen now and subscribe.