Newsletter | March 10, 2023

03.10.23 -- Enabling And Advancing RNA-LNP From Concept To Clinic

How Outsourcing RNA-LNP Production Can Have A Competitive Advantage

Manufacturing the RNA-containing LNPs is a complex process and demands specialized expertise and experience. Developing a drug is time-consuming, complex, and multifaceted, requiring enormous investment and extensive resources. Explore some of the challenges of RNA-LNP drug manufacturing, along with the advantages of outsourcing RNA-LNP formulations.

Analytics And Bioassays Can Safely Fast-Track mRNA-LNP Drug Development

mRNA technology is new and still in the early stages, with no standardized manufacturing protocols. One of the biggest challenges is the formulation of mRNA delivery systems such as lipid nanoparticles (LNPs). Learn about evading impurities in lipids, the significance of the 'biological readout,' and the future of mRNA-based genomic medicines.

Key Stages In mRNA-Based Therapeutic Development

Fueled by the success of the mRNA-based COVID-19 vaccines, RNA-based medicines are poised to revolutionize the pharmaceutical industry. Each phase of mRNA-based therapeutic development consists of specific goals, steps, and end points. Learn the fundamentals of manufacturing mRNA-lipid nanoparticle (LNP) drug products from discovery to commercialization.

Genome Editing of Human Primary T Cells With Lipid Nanoparticles

A promising new approach for T-cell engineering is the use of RNA to express therapeutic proteins and gene editing nucleases. Explore optimization strategies for T-cell gene editing, CRISPR/Cas9-mediated knockouts of the T-cell receptor, multistep LNP engineering to produce TCRÉ‘Β KO CAR T cells, and more.

Develop A Successful mRNA Vaccine Program

Learn the fundamentals of mRNA vaccine development with NanoMedU, a live, virtual course on genomic medicines. Understand the pillars of a successful mRNA vaccine program, including formulation development considerations and how process parameters affect outcomes.