The ability to interrogate protein phosphorylation events and aberrant phosphorylation levels is critical to our understanding of various biological and pathological processes, particularly in the research of diseases, like cancer. However, detection of phosphorylated proteins in western blots can be challenging. Following are ten tips to ensure robust data generation and cleaner blots.
Traditionally, new chemicals are developed using batch processing, which fully relies on versatile and qualified equipment to perform different unit operations. To address these challenges, continuous flow chemistry technology is emerging as an effective tool to conduct chemical synthesis.
The new business model of the biopharmaceutical industry that focuses on the unmet needs of smaller patient populations has diversified today’s pipelines and brought new hope to patient care. To meet an aggressive timeline with a lack of resources, Kaleido Biosciences had to consider an alternative yet efficient route.
Critical quality attributes (CQA) are fundamental to regulatory compliance and typically include data on how the candidate interacts with target proteins, size, and purity. This poster booklet provides a snapshot on how different analytical technologies have been used to look into aspects related to the efficacy, stability, and safety of therapeutic candidates.