Newsletter | June 28, 2022

06.28.22 -- 3 Tips For Purifying His-Tagged Proteins

 
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3 Tips For Purifying His-Tagged Proteins

Tags simplify purification and enable scientists to use standard protocols while also improving the yield, purity, and solubility of the protein of interest.

Mitigating The Potential For Immunogenicity

New assays that can more accurately predict how the human body will react to a drug candidate are now available, but their success is dependent on several factors.

Orthogonal Fragmentation Mechanism Enables New Levels Of Metabolite Characterization

Fragmentation is required to provide structural information about metabolites during drug discovery. Here, two orthogonal fragmentation techniques are compared to determine the in vitro metabolism of the drug darunavir.

Engineering Approaches To Respiratory Drug Delivery: Mannitol Case Study

This article presents a case study that explores the material and performance properties of spray-dried and jet-milled mannitol for respiratory delivery of crystalline mannitol.

Rapid Characterization Of Impurities

Understand how to manage impurities in drug development with swift isolation, synthesis, and analysis. A client discovered an impurity during ongoing stability studies that exceeded ICH guidelines.

Integrated Predictive Sciences Solutions To Accelerate Drug Discovery And Innovation

Learn how having the right predictive sciences capabilities integrated into R&D workflows delivers a scientific decision support environment that reduces time and expense, improves quality, enhances collaboration, and accelerates innovation in bringing new drugs to market.

The Advantages And Challenges Of Fixed-Dose Combination Products

Understanding the significant competitive advantages of FDC products and the difficulties and potential pitfalls associated with their development and manufacturing in oral solid dosage forms is critical.

Enabling Technologies To Increase Spray-Drying Throughput For Brick Dust Compounds

We discuss three enabling technologies designed to improve drug solubility in organic solvents for spray drying and define the advantages and risks of each technology.

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