Application Note: Fail-Early Approach To Compound Screening Using A Dual Nuclear Staining Assay

Toxicity studies are an essential component of progressing compounds through the drug discovery process. Molecules must be screened for non-specific, adverse biological properties such as cytotoxicity. As a significant number of compounds fail during ADMETox due to their toxicity, it is of paramount importance to have an effective early indication of any compounds that exhibit cytotoxic effects.