DRUG DISCOVERY FEATURED ARTICLES & APPLICATIONS

  • Imaging And Analysis Of A High Density Cell Migration Assay
    Imaging And Analysis Of A High Density Cell Migration Assay

    Complex biological or environmental signaling events can lead to cell migration, the movement of cells from one location to another. The migration of cells commonly occurs during both normal biological processes such as the development of an organism or marking pathological events such as cancer metastasis. Automated processes in higher density formats improve throughput greatly increasing the usefulness of performing migration assays at a larger scale. This study evaluated the use of a high density cell exclusion assay in 384- well format for investigation of cell migration using a cell line stably expressing green fluorescent protein (GFP).

  • Getting The Most Out Of Your Viral Clearance Study

    By John Zehmer, PhD, Senior Scientist and Study Director at BioReliance

    Conducting a viral clearance study is an important step on the road toward getting your biomolecule into the clinic and on its way to becoming a drug. However, since most companies do not have the systems in place to support a regulated virological study of this kind, this will likely mean engaging a contract research organization (CRO) as a partner. The keys to meeting your goals are solid planning and good communication between your group and your CRO partner. This article provides a high-level review of these processes and will aid in planning for a successful study.

  • Tools for the Design of Vaccines to Help Reduce Clinical Failure

    If you are involved in the pharma industry, then you are interested in saving lives. In the area of preventative medicine, therapeutic vaccines have proven to have a tremendous impact on the ability to save millions of lives. Similar to pharmaceuticals, vaccine development can take over 10 years and less than 10 percent of candidates reach commercialization. Reducing the cost of failure and increasing the chances of clinical success for vaccines is beneficial to both the pharma industry and those being treated for or protected from disease.

  • Patheon Surfs Outsourcing Waves And Scoops Up Gallus Along The Way

    Jim Mullen, CEO of Patheon parent company DPx Holdings B.V., is at it again.

    On the heels of my three-part series with Mullen on the details behind the springtime merger of his company and the pharmaceutical products division of Royal DSM, he has made his next move.

    This time it is a strategic entrée into the U.S.-based market for biologics services via an acquisition of privately held Gallus BioPharmaceuticals. With Gallus, Patheon adds new capabilities at well-established sites with name-brand clientele, in St. Louis, Mo. and Princeton, N.J., to its global locations in Groningen, the Netherlands and Brisbane, Australia.

  • Systematic Method Development Of UPC2 Conditions Using Opioid Drugs

    This application note uses a panel of natural and synthetic opioid drugs to demonstrate the use of a systematic screening strategy for UPC2 method development. By Jonathan P. Danaceau, Kenneth J. Fountain, and Erin E. Chambers, Waters Corporation

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LATEST NEWS

  • Molecular Devices Partners With Roche To Develop Custom Ruthenium Nano-TRF® Detection Platform
    Molecular Devices Partners With Roche To Develop Custom Ruthenium Nano-TRF® Detection Platform

    The custom technologies arm of Molecular Devices, a leader in bioanalytical systems for drug discovery, life science research, and bioassay development, has partnered with the Discovery Technologies team at the Roche Innovation Center Basel of Pharma Research and Early Development (pRED) to develop a high-throughput detection system for drug discovery screens employing Roche's proprietary Ruthenium-based nanosecond time resolved fluorescence (Nano-TRF®) assays

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FEATURED PRODUCTS AND SERVICES

Mercury Analyzer

Mercury Analyzer

The AULA 254 ASD. Automatic Mercury Analyzer with sample digestion is used for fully automatic determination of mercury traces in aqueous samples...

Multiskan EX

Multiskan - Microplate Photometer
Analytical Method Development & Validation

Analytical Method Development & Validation

Patheon is the most rapid and cost-effective way to go from molecule to market by integrating analytical method development and validation into a program driven by expertise.

Drug Classifications Manual

The Controlled Substances Handbook provides adjustments in drug classifications or modifications to management requirements, as well as additions or amendments to Drug Enforcement Administration (DEA) regulations...
Ensuring Cold Chain Remains Cold And Control Room Temperature Remains Controlled!

Ensuring Cold Chain Remains Cold And Control Room Temperature Remains Controlled!

Qualification testing for the newest additions to the World Courier Ground Europe suite of vehicles has just been completed at Cambridge Refrigeration Technology (CRT) and the results are looking very impressive.

Petroleum Sorbent Roll

Petroleum Sorbent Roll

The Petroleum Sorbent Roll, High Capacity is a selective sorbent which will "sorb" hydrocarbon-based liquids (oleophilic) and repel aqueous based liquids (hydrophobic).
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Stability Programs - Key Factors in Meeting FDA/ICH Regulations

December 10, 2014
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Stability Programs - Key Factors in Meeting FDA/ICH Regulations

December 10, 2014
1pm-2:30pm EST, Online Training

Building Accountability on Your Clinical Teams

January 8, 2015
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Pediatric Clinical Trials: Special Considerations and Requirements

January 12, 2015
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Root Cause Analysis for GCP – A Risk Action Plan Guide

January 16, 2015
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