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DRUG DISCOVERY FEATURED ARTICLES & APPLICATIONS

  • Kinetic Ligand Binding And 3D Tumor Invasion Technologies To Assess Drug Residence Time And Anti-metastatic Effects
    Kinetic Ligand Binding And 3D Tumor Invasion Technologies To Assess Drug Residence Time And Anti-metastatic Effects

    Metastasis, the spread of cancer cells from the original tumor to secondary locations within the body, is linked to approximately 90% of cancer deaths. The expression of chemokine receptors, such as CXCR4 and CCR7, is tightly correlated with the metastatic properties of breast cancer cells. In vivo, neutralizing the interaction of CXCR4 and its known ligand, SDF1-α (CXCL12), significantly impaired the metastasis of breast cancer cells and cell migration.

  • Label-Free Phenotype MicroArrays™ Analysis Of Cellular Energetics And Apoptotic Activity Using Microplate Reading And Phase Contrast Imaging

    Phenotypic screening, or the determination of the effects (phenotypes) that a molecule has on a cell, tissue, or whole organism, dates back to earliest drug discovery efforts.

  • Dermal Toxicology: A Multifaceted Approach To Meet Today’s Research Needs

    Developing a dermal NCE generally follows the same path as other small molecule NCEs administered orally or systemically, except that the dermal route is used in a non-rodent model.

  • Imaging And Analysis Of A High Density Cell Migration Assay

    Complex biological or environmental signaling events can lead to cell migration, the movement of cells from one location to another. The migration of cells commonly occurs during both normal biological processes such as the development of an organism or marking pathological events such as cancer metastasis. Automated processes in higher density formats improve throughput greatly increasing the usefulness of performing migration assays at a larger scale. This study evaluated the use of a high density cell exclusion assay in 384- well format for investigation of cell migration using a cell line stably expressing green fluorescent protein (GFP).

  • Getting The Most Out Of Your Viral Clearance Study

    By John Zehmer, PhD, Senior Scientist and Study Director at BioReliance

    Conducting a viral clearance study is an important step on the road toward getting your biomolecule into the clinic and on its way to becoming a drug. However, since most companies do not have the systems in place to support a regulated virological study of this kind, this will likely mean engaging a contract research organization (CRO) as a partner. The keys to meeting your goals are solid planning and good communication between your group and your CRO partner. This article provides a high-level review of these processes and will aid in planning for a successful study.

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LATEST NEWS

  • Emmaus Life Sciences To Present Phase 3 Sickle Cell Disease Clinical Trial Data

    Emmaus Life Sciences, Inc., a biopharmaceutical company dedicated primarily to the discovery, development and commercialization of innovative treatments and therapies for rare and orphan diseases recently announced that data from the Company’s Phase 3 clinical trial of its pharmaceutical grade L-glutamine (PGLG) treatment for sickle cell anemia and sickle beta-0 thalassemia, will be presented, during the 9th Annual Sickle Cell Disease Research and Educational Symposium and 38th National Sickle Cell Disease Scientific Meeting

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Engineered Enclosures

Engineered Enclosures

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Regulatory Dossier Support Services

Regulatory Dossier Support Services

The key to a delay-free submission is completeness and accuracy. Patheon's regulatory dossier support is a perfect example of the strength of our experience and fully integrated approach to late development. 

Laboratory Refrigerator/Freezer

Laboratory Refrigerator/Freezer

The Model RCRF252A14 25-cu-ft laboratory refrigerator/freezer combination is a two-door unit that features a ± 4°C refrigerator cabinet, a –15°C freezer cabinet, and forced air circulation...
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Compact Scales

The Compact series of scales welcomes a new addition to its expanding family of portable balances...

Liquent Submission Accelerator™

Leverage Liquent CoreDossier to automatically produce eCTD submissions.
Resins for Solid Phase Chemistry

Resins for Solid Phase Chemistry

TentaGel and Polystyrene resins were designed for solid phase chemistry (combinatorial chemistry, library generation, peptide and oligonucleotide synthesis)
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INDUSTRY EVENTS

Communication With FDA: What Do We Say And How Do We Say It?

April 28, 2015
1pm-2:30pm EDT, Online Training

Process Validation: Ensuring Compliance With Multiple Standards

May 6, 2015
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Top IND Pitfalls & How to Avoid Them

May 7, 2015
1pm-2:30pm EDT, Online Training
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 UPCOMING TRAINING COURSES

Communication With FDA: What Do We Say And How Do We Say It?

April 28, 2015
1pm-2:30pm EDT, Online Training

Process Validation: Ensuring Compliance With Multiple Standards

May 6, 2015
1pm-2:30pm EDT, Online Training

Top IND Pitfalls & How to Avoid Them

May 7, 2015
1pm-2:30pm EDT, Online Training
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